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183 In addition, Small molecule antagonists which inhibit TGF- receptor kinase or TGF- activated pathways were studied, 184,185 although the long-term safety of such drugs might be a problem, particularly as TGF- affects tissue repair and is a potent anti-inflammatory mediator (Table 3)

Arsenault BJ , Boekholdt M , Dub MP , et al

Studies have also examined ARA-290 in the context of metabolic stress, pain signaling, and immune cell mediated pathways, with interpretation depending on model design and exposure conditions

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The primers used to generate MEIS1 deletion are listed in the Reagents and Tools Table